2M Potassium Acetate Solution
CAS NO.: 127-08-2
Molecular Formula: CH3COOK
Molecular Weight: 98.14
Character: Clear, colorless aqueous solution with a nominal concentration of 2 mol/L.
Usage:
1. It is used for laboratory buffer preparation and chemical analysis;
2. It is used in biochemical and molecular biology procedures;
3. It can be used as a standardized potassium acetate reagent solution.
Package: 1L, 5L or customized laboratory packaging.
Storage: It should be stored in a dry, cool and well-ventilated warehouse, kept away from heat and direct sunlight during storage and transportation, and handled with care to avoid package damage. Furthermore, it must be stored separately from strong acids, poisonous substances and incompatible materials.
- Product Description
2M Potassium Acetate Solution for Laboratory & Biochemical Applications | Ready-to-Use Buffer System
SHANXI ZHAOYI CHEMICAL CO., LTD. has made acetate chemicals since 1988. That adds up to more than 35 years of independent production. Our plant covers 27,000 m² and turns out 150,000 tons of acetate a year. Labs and biochemical firms around the world buy their reagent solutions from us, and they expect tight precision. One example is our 2M Potassium Acetate Solution (CAS 127-08-2). It comes as a clear, colorless buffer already mixed in water at 2.0 mol/L. Nothing has to be weighed. Nothing has to be dissolved or adjusted either. Because the bottle is ready to use, human mistakes drop away and the data holds steady run after run. Every batch passes strict quality control, with the concentration held within ±2%. ISO, KOSHER and HALAL certificates cover the full range. Molecular biology experiments, biochemical testing and routine lab analysis all get what they need from it.

Key Features & Benefits
Our this product is professionally optimized for laboratory and biochemical application scenarios, with prominent practical advantages compared with self-prepared reagents and ordinary buffer solutions:
Immediate Laboratory Readiness: We mix it to the 2.0 mol/L spec, so the bottle is ready the moment you open it. Making buffer by hand brings its own trouble. Someone weighs badly. Powder fails to dissolve. Two batches end up at different strengths. None of that happens here. Work moves faster, and your data repeats.
Molecular Biology Optimized: pH stays steady and purity runs high, so this buffer suits strict DNA/RNA precipitation work and many enzyme reaction systems. It brings in no impurities and does not get in the way of the reaction. Sensitive biochemical assays keep running without a hitch.
Extended Shelf Stability: The maker's own stabilization step keeps the solution at a steady strength. Sealed and stored as usual, it stays good for up to 24 months. Fewer bottles spoil. Keeping it a long time means less waste. Lab tests cost less in the end.
Multi-Application Versatility: Day to day, labs use it to make standard buffers. Acid-base titration is another use. For ion exchange chromatography, labs add it to mobile phases. It can serve in quality calibration as well. Many kinds of tests and experiments can use it.

Technical Specifications
Parameter | Specification |
Product Name | 2M Potassium Acetate Solution |
CAS Number | 127-08-2 |
Molecular Formula | CH₃COOK |
Molecular Weight | 98.14 g/mol |
Concentration | 2.0 mol/L (±2%) |
Appearance | Clear, colorless liquid |
pH Range | 7.5 - 9.0 (typical) |
Density | ~1.13 g/cm³ at 20°C |
Packaging Options | 1L, 5L, customized volumes |
Shelf Life | 24 months (sealed, proper storage) |

How It Works
Its ion ratio is precise. Chemical properties hold steady. That makes this product a reliable buffer system. Across many labs, it has a clear role:
Stable Buffering Mechanism: Potassium ions and acetate anions are in the solution at balanced levels. Acetate behaves as a weak conjugate base. With acetic acid, it creates a steady acid-base buffer system. Any sudden pH shift in the solution gets stopped. That keeps the test environment stable.
Nucleic Acid Purification Effect: In alkaline lysis DNA extraction, it neutralizes SDS-protein complexes that form during cell lysis. Impurity proteins and cell debris fall out of solution. That removal is targeted. Nucleic acid molecules stay soluble. Purity of the extracted plasmid DNA rises a lot.
Accurate Titration Calibration: The concentration indicators it has are fixed and exact. So it can serve as a standard reagent for acid-base titration tests. Volumetric analysis lets you work out the concentration of an unknown acid. The analytical data comes out accurate and credible.
Applications
Stability is what this lab buffer solution is known for. Biochemistry research puts it to work. So does analytical chemistry testing. Lab quality control is another area it covers. Other main fields use it as well. Research institutions and testing labs worldwide depend on it:
Biochemical Research: One reagent you cannot skip here is this one, used to extract plasmid DNA with alkaline lysis technology. Genomic DNA gets separated from protein impurities, and it does that job well. The target plasmid DNA comes out separately too. Molecular experiments then have clean, high-purity nucleic acid samples to work with.
Buffer Preparation: Mix it with acetic acid and you end up with an acetate buffer system that performs well. Between 3.6-5.5 the pH holds steady. Enzyme activity detection is one job many labs give it. Protein electrophoresis shows up often too. Experiments that demand tight pH control are a good fit as well.
Chemical Analysis: Quantitative titration detection is one use. Preparing mobile phases for ion chromatography is another. Spectrophotometric analysis fits as well. Ionic strength stays steady inside the experimental system. That is what keeps detection results repeatable.
Quality Control Laboratories: Pharmaceutical and food testing projects often use it for method verification and instrument calibration. It works as a standard reference reagent that can be traced. Lab quality management and compliance testing needs get covered by it too.
2M Potassium Acetate Solution vs Other Products
Feature | 2M Potassium Acetate Solution | Sodium Acetate Buffer | Tris-HCl Buffer | DIY Powder Preparation |
Ready-to-Use | ✓ Immediate | ✓ Immediate | ✓ Immediate | ✗ Requires dissolution |
DNA Precipitation | ✓ Optimal | ✗ Protein co-precipitation | ✗ Not suitable | ✓ If prepared correctly |
Preparation Time | 0 minutes | 0 minutes | 0 minutes | 15-30 minutes |
Concentration Accuracy | ±2% guaranteed | ±2% guaranteed | ±3% typical | ±5-10% user-dependent |
Shelf Stability | 24 months | 18 months | 12 months | Immediate use recommended |
Cost Efficiency | High (volume) | Medium | Medium | Low (labor + error risk) |
Certifications & Compliance
The ISO 9001 quality management system is followed to the letter in our production workshop. Production and testing steps all get standardized this way. All reagents carry KOSHER and HALAL certification. Laboratories with special scenarios can then use them under their own compliance rules. Each batch of this product ships with its own batch-specific Certificate of Analysis (CoA) and Material Safety Data Sheet (MSDS). Traceability data is complete. It backs up customer laboratory compliance management and experimental verification.

Packaging Options
We provide diversified standardized and customized packaging solutions to adapt to different laboratory usage frequencies and experimental scales:
1-Liter Bottles: Adopting chemical-resistant HDPE material with clear scale marks and sealed leak-proof caps, it is very suitable for daily conventional laboratory experiments, effectively reducing reagent contamination risks.
5-Liter Containers: Cost-effective large-capacity packaging, equipped with sturdy handles and drip-proof pouring nozzles, convenient for safe liquid taking and transportation, ideal for high-throughput laboratories with large reagent consumption.
Custom Volumes: We support customized packaging of more than 20 liters, which can adapt to automated liquid handling equipment and long-term bulk procurement needs of institutional laboratories and research institutions.

Manufacturing Process
We use pharmaceutical-grade potassium acetate crystals as our raw material. They come from our own 27,000 m² standardized factory, where we produce and process them. That keeps the material pure and the supply steady. To dissolve the crystals, we use high-resistivity deionized water. Its resistivity is >15 MΩ·cm. The temperature stays constant the whole time. This stops impurities from getting mixed in.
A precision gravimetric dilution method sets the target concentration at 2.0 mol/L. Titration and conductivity tests are among the checks we run. They confirm the concentration is accurate. We also pass the solution through multi-stage precision filters. These filters take out every particulate impurity larger than 0.22 microns.
Filling happens in an ISO Class 7 clean workshop, under aseptic conditions. Each batch gets its own number. Production testing records and traceability files are kept for every one. That fully meets global laboratory reagent quality standards and regulatory requirements.
Why Choose Us
Acetate products are all we have made for 35 years. Nothing else. That focus has paid off. Today more than 10,000 professional laboratories across Europe, America, Asia, and other regions use our products. We can turn out 150,000 tons a year. Swings in market demand are easier to absorb that way, and orders keep moving out on time.
As a direct manufacturer, we eliminate intermediate distributor price differences and provide customers with cost-effective factory direct sales prices. Our professional technical team provides free experimental application guidance and customized formula consultation services to solve customers' experimental matching problems.
Our logistics system is mature and covers more than 40 countries. We use constant-temperature packaging and transport for shipping. On long trips, reagent properties stay stable. Goods also reach the buyer whole.

FAQ
Q: Can you autoclave this solution to make it sterile?
A: A1: Yes. Autoclaving at 121°C for 15 minutes is safe. The solution's properties will not be harmed. Let it cool down to room temperature first. Your concentration and test results then stay accurate.
Q: What makes a stored solution turn cloudy, or form crystals?
A: A2: Crystals can show up if you store it below 10°C. Warm it gently to 25°C and mix it evenly. The crystals will dissolve again. The original concentration does not change, and neither does the way the reagent works.
Q: Does this solution work for GMP-grade pharmaceutical production?
A: A3: Our standard grade fits regular lab research. Need GMP pharmaceutical manufacturing instead? We can supply pharma-grade products. We also provide the DMF certification papers that go with them, if you ask.
Q: After I open the container, what is the right way to store the reagents?
A: A4: Seal the bottle tight each time you are done with it. Store it in a dry place at 15-25°C. Keep it away from direct sunlight. Use clean pipettes when you take liquid out, so nothing gets cross-contaminated.
Q: Do you support custom concentration configuration?
A: A5: We support customer-tailored concentration production. For small-batch use, you can dilute it with deionized water according to experimental needs; we provide professional customized services for large-volume orders.

Request a Quote
If you are in need of high-purity, 2M Potassium Acetate Solution please feel free to contact our professional sales team via email:sxzy@sxzhaoyi.com.


